US 51 enters Tennessee at Memphis and runs north through the cities of Millington, Munford, Atoka, Brighton, Covington, Henning, Ripley, Halls, Dyersburg, Troy, Union City, and South Fulton. This highway crosses four interstate highways on its journey through the state and actually crosses Interstate 240 twice within the City of Memphis but interchanges with it only at Union Avenue. US 51 is the westernmost south-north United States Highway in the State of Tennessee. US 51 is an interstate standard facility from Dyersburg to South of Troy and then resuming interstate standard status north of Union City to South Fulton. US 51 is a four-lane or larger facility throughout the state with some sections north of Dyersburg carrying a speed limit. Near Henning is also the site of the Hatchie RiverBridge collapse on April 1, 1989 that killed 8 motorists when 3 spans of the structure collapsed. The 54-year-old bridge was north of Memphis and carried the northbound lanes of US 51. Its collapse was the result of pier scour and movement of the river channel. US 51 carries the Tennessee Scenic Parkway designation from its junction with SR 385 in Millington to SR 104 in Dyersburg and also carries the Great River Road designation from US 64/US 70/US 79 in Memphis to SR 88 in Halls.
Most of US 51 north of Dyersburg is expected to be upgraded as part of future Interstate 69. Plans currently call for Interstate 69 to run along the existing US 51 freeway from Dyersburg to Troy and from Union City to South Fulton. This section is part of SIU 7 for Interstate 69 and will require few changes beyond resigning the existing highway, however, a bypass route around Troy and Union City will need to be built before this section of future Interstate 69 is completed.
U.S. Route 51 Business is a business route of US 51 located entirely in the city of Dyersburg in Dyer County, Tennessee. It has the unsigned designation of State Route 211 for its entire length. The highway begins as South Main Avenue at a large three-way intersection with US 51/SR 3 on the southern edge of the city. It heads north, concurrent with SR 211, as a two-lane road through a business district before traveling through wooded areas and crossing a bridge over the North Fork of the Forked Deer River into downtown. US 51 Bus./SR 211 pass by the Dyer County Courthouse and becomes concurrent with SR 104 as the road becomes North Main Avenue shortly before making an abrupt left turn onto McGaughey Street. US 51 Bus./SR 211 then split before heading through neighborhoods along Troy Avenue before turning right onto Gordon Street. The highway then makes a left turn onto North Sampson Avenue and passes through more neighborhoods before merging onto Saint John Avenue. They then travel through a business district before widening to a four-lane highway and coming to an end at an intersection with US 51/SR 3, where US 51 Bus. ends and SR 211 follows northbound US 51/SR 3 north on Saint John Avenue.
