US 2 enters the state from Minnesota at the city of Superior on the Bong Memorial Bridge. US 2 then follows Belknap Street eastbound, passing through downtown Superior, where it has an intersection with Wisconsin Highway 35. US 2 then continues east for to its intersection with US 53. At this point, the two highways then run concurrently southeasterly on a four-lane surface street for. After the intersection with Moccasin Mike Road, a freeway segment begins for US 2/US 53 as the highway leaves the city of Superior together. US 2/US 53 has an interchange with WIS 13 near Parkland; WIS 13 begins its course around the Lake Superior shoreline at this point. US 2 and US 53 split in South Range at an unusual interchange at which westbound US 2 traffic must cross over the freeway to the eastbound lanes to access US 53 south. US 2 then continues independently again as a two-lane road, passing through Wentworth, Poplar, and Maple as it heads east to the Douglas–Bayfield county line at Brule. Just west of Brule, US 2 crosses the Brule River State Forest. in Florence In Bayfield County, US 2 passes through Iron River then proceeds east-southeasterly through the Chequamegon National Forest and to Ino where it turns east and meets US 63's northern terminus at about east of Ino. US 2 turns northeastward and meets WIS 13, which joins it eastbound as they follow the Lake Superior shoreline closely to the Ashland County line and the City of Ashland. WIS 13 turns south in downtown Ashland while US 2 follows the lakeshore northeastward and turns east at the city limit and proceeds to Odanah and turns southeastward to the Iron County line. the highway junctions with WIS 169 east of the county line then turns eastward to Saxon where it crosses WIS 122. US 2 then continues east, then southeast toward Hurley where it meets US 51 at its northern terminus and immediately enters Michigan.
Eastern segment
US 2 re-enters Wisconsin from Iron County, Michigan concurrently with US 141 and turns southeastward to Florence and intersects WIS 70/WIS 101 at their shared terminus. After a short trek through Florence via Central Avenue, Furnace Street and Florence Avenue, the highway turns south and passes by Commonwealth then turns east and passes through the community of Spread Eagle. The highway returns into Michigan east of Spread Eagle.
History
In 1918, the western segment of US 2 was old WIS 10 with the exception of the short segment between US 51 and the Michigan state line, which was not a part of the state highway system until Michigan signed their trunkline system a year later. The entire eastern segment was designated as old WIS 69 in 1918. One business route existed for US 2 until 2002. Business US 2 began at the US 51 terminus and headed southeast to WIS 77 in downtown Hurley where it turned east into Michigan. Although Michigan still has the route signed, Wisconsin removed its signs. The street in Hurley that runs from WIS 77 to the border is still a state trunkline despite not having a numbered designation.
