US 11 enters Tennessee west of Chattanooga. The route, concurrent with SR 38 from the state line north, runs parallel to Interstate 24 for three miles to an intersection with Cummings Highway. While SR 38 terminates here, US 11 follows the highway east into downtown Chattanooga. At the intersection of Broad Street and East 23rd Street, US 11 and US 64 separate from US 41 and US 72 and follow East 23rd east through downtown. The routes briefly overlap with US 41, here concurrent to US 76, on Dodds Avenue before resuming an easterly progression on Brainerd Road thereafter called Lee Highway. East of downtown, I-24 terminates while Interstate 75 continues east along the I-24 right-of-way. US 11 and US 64 continue to the northeast, through northern Chattanooga, and run concurrent with I-75 between exits 7 and 11. State Route 317 runs concurrent with I-75 between exits 7 and 9. At exit 11, the route splits, running through Ooltewah and Collegedale before entering Bradley County. The route travels north to Cleveland and comes to an interchange with APD-40. In downtown Cleveland, US 64 separates from US 11, following State Route 40 east out of the city. US 11 parallels I-75 as it heads north, passing through Athens, where it intersects with SR 30Sweetwater, where it intersects SR 68, Loudon, where it intersects SR 72, and Lenoir City where it intersects with US 321/SR 95. The route then forms a concurrency with US 70 at Dixie Lee Junction and enters Knox County passing first through Farragut and then entering West Knoxville. The route comes to an intersection with SR 131 and then I-140. In downtown Knoxville, the routes intersect with US 129. US 11 and US 70 split east of Knoxville, and split into US 11E and US 11W. US 11W goes through Rutledge, Bean Station, Rogersville, and Kingsport. US 11E goes through Jefferson City, Morristown, Russellville, Greeneville, Jonesborough, Johnson City, where the route forms a concurrency with US 19, and Bristol, before crossing into Virginia.
The longest segment of the original concrete U.S. Route 11 located in Charleston was listed on the National Register of Historic Places on January 10, 2008 as the Cleveland to Charleston Concrete Highway. This segment was built from 1925 to 1927, and now consists of Market and Water Streets, and runs from U.S. 11 to the Hiwassee River where the original bridge was located.
