Lee was born in Whitechapel, London. His father was a singer. He learned the rudiments of the piano from his elder brother, Arthur, who was self-taught and preferred to use the black keys rather than the white. As a consequence, he became fluent in keys such as G flat and B natural, before moving on to more standard keys, leaving him with the ability to transpose effortlessly his entire repertoire into any key. He played as a regular for many years with a trio comprising bassist Tony Archer and drummer Martin Drew or Terry Jenkins at The Bull's Head in Barnes, South West London, a few miles from his home in Kingston upon Thames, Surrey. During a visit by the former Count Basie tenor-saxophonist Billy Mitchell who came to play at the Bull's Head, both Mitchell and Lee got on so well together that the Bull's Dan Fleming organised for both of them to tour in the US in 1984. Fleming said at the time, "Lee could bring out the best in everybody and he drew you into the music." Despite his sketchy knowledge of musical theory, he was a complete master of his instrument, and blessed with large hands,, his solos ranged from effortless large block chords to delicate single note figures, all played in a lyrical style, and swinging like a garden gate. He was arguably the greatest British exponent of the Erroll Garner piano style, though his playing embraced a much wider compass. He appeared on at least two recordings with Seamen - Phil Seamen Now!... Live! and on Phil Seamen Meets Eddie Gomez, a live recording featuring US bassist Eddie Gómez. His solo debut, Electric Piano, earned many comparisons to the works of Burt Bacharach. He made at least four other LPs, including Tony Lee Trio , probably the quintessential album of his career, Street of Dreams, Hey There and The Tony Lee Trio Live at the Station, prior to his death from cancer in 2004. He had a long-lasting association of some 40 years with bassist Tony Archer in the Tony Lee Trio. Lee and Archer also played together in the sextet The Best of British Jazz formed in the early 1970s with Jack Parnell, Kenny Baker, Don Lusher and Betty Smith. The sextet recorded two albums - The Best of British Jazz and The Very Best ofBritish Jazz. As with many pianists from the 1950s and 1960s Lee was influenced by Errol Garner, Oscar Peterson and Art Tatum.
