Between 2012 and 2014, Luwawu-Cabarrot played a total of five games for Antibes Sharks. In January 2014, he signed his first pro deal with Antibes, and in 2014–15, he became a full squad member for the first time. In 42 games for Antibes in 2014–15, he averaged 7.1 points, 2.5 rebounds, 1.6 assists, and 1.1 steals per game. He also helped the team win the LNB Pro B Leaders Cup. He originally planned to enter the 2015 NBA draft, but ultimately did not.
On July 5, 2015, Luwawu-Cabarrot signed with Mega Leks of Serbia for the 2015–16 season. He helped the club win the Serbian Cup, and at the season's end, he earned All-ABA League Team honours. In 28 ABA League games for Mega Leks, he averaged 14.6 points, 4.8 rebounds, 2.8 assists and 1.7 steals per game.
Philadelphia 76ers (2016–2018)
In April 2016, Luwawu-Cabarrot declared for the 2016 NBA draft. He was subsequently selected with the 24th overall pick in the draft by the Philadelphia 76ers. On July 3, 2016, he signed his rookie scale contract with the 76ers and joined the team for the 2016 NBA Summer League. On October 29, 2016, he made his NBA debut in a 104–72 loss to the Atlanta Hawks, recording one rebound, one assist and one steal in six minutes off the bench. On February 1, 2017, he made the first start of his career in place of the injured Robert Covington and scored seven points in a 113–95 loss to the Dallas Mavericks. On March 12, 2017, he scored a season-high 18 points in a 118–116 win over the Los Angeles Lakers. On March 31, 2017, he set a new season high with 19 points in a 122–105 loss to the Cleveland Cavaliers. Two days later, he had a 23-point effort in a 113–105 loss to the Toronto Raptors. On April 10, 2017, he scored a season-best 24 points in a 120–111 loss to the Indiana Pacers. During his rookie season, he had multiple assignments to the Delaware 87ers of the NBA Development League.
On February 1, 2019, Luwawu-Cabarrot was traded with cash considerations to the Chicago Bulls in exchange for a protected 2020 second-round draft pick.
Brooklyn Nets (2019–present)
On September 30, 2019, Luwawu-Cabarrot joined the Cleveland Cavaliers for training camp and played two preseason games before being waived. On October 23, 2019, Luwawu-Cabarrot signed a two-way contract with the Brooklyn Nets. On January 15, 2020, the Nets announced that they had signed Luwawu-Cabarrot to a 10-day contract. On January 25, he was signed to a second 10-day contract. On February 7, Luwawu-Cabarrot signed a multi-year contract with the Nets.
