Tiberio Crispo, the son of Giovanni Battista Crispo and Silvia Ruffini, who, after her husband's death, was the mistress of Alessandro Farnese. It was believed that Tiberio was an illegitimate son of Farnese, who became Pope Paul III. He was certainly a natural brother of Costanza Farnese and Ranuccio Farnese, the two undisputed legitimate children of Paul III, were born before his election as pope in 1534.
Biography
Tiberio Crispo began his career as a Canon and Prebendary of the Vatican Basilica. On April 11, 1543, Pope Paul III granted him the right of making his own will. He was also cubicularius secretus. From June, 1542 to April, 1545, Crispo was the castellan of Castel Sant'Angelo. He was appointed Bishop of Sessa Aurunca in Campania, in the province of Caserta in the Kingdom of Naples, on July 6, 1543, though he resigned the post in the next year in favor Bartolommeo Albano, who was appointed on June 7, 1544. Tiberio Crispo was raised to the cardinalate on December 19, 1544 by Paul III. He was assigned the deaconry of S. Agata de' Goti from 1545 to 1551. On November 20, 1551 he was promoted to the Order of Cardinal Priests, but he was allowed to continue to hold the deaconry of S. Agata as though it were a titulus, pro illa vice until 1562. On May 18, 1562 he was promoted Cardinal Priest of S. Maria in Trastevere. He was appointed Administrator of the Diocese of Sessa Aurunca, during the vacancy caused by the death of Bishop Galeazzo Florimonte. As papal legate to Perugia, Crispo was a "driving force behind the architectural renewal of the city". For example, in 1547 Crispo commissioned Galeazzo Alessi for the construction of Santa Maria del Popolo to replace a church demolished by the construction of the Via Nuova. He also commissioned a palace in Bolsena that bears his name, Palazzo di Tiberio Crispo, which was designed by Antonio da Sangallo the Younger circa 1543; after the death of Sangallo in 1546, Raffaello da Montelupo was called in to finish the palace, which remained incomplete, however, after the deaths of both Crispo and Raffaello in 1566. Historical research indicates that Crispo also likely owned the "Palazzo Nobile" in Rome, a palace originally commissioned for Thomas Cardinal Wolsey circa 1507 before passing to the Aldobrandini family; Crispo likely commissioned the 400 square metres of frescos in the palace which celebrate the life of Paul III. After the death of Paul III, Crispo participated in the conclaves of 1549-1550, April 1555, May 1555, 1559, 1565-1566. Research related to the life and patronage of Crispo is ongoing in historical archives in Rome and Umbria.