In 1810 he travelled to the Great Lakes and in 1811 travelled on the Astor Expedition led by William Price Hunt on behalf of John Jacob Astor up the Missouri River. Nuttall was accompanied by the English botanist John Bradbury, who was collecting plants on behalf of Liverpool botanical gardens. Nuttall and Bradbury left the party at the trading post with the Arikara Indians in South Dakota, and continued farther upriver with Ramsay Crooks. In August they returned to the Arikara post and joined Manuel Lisa's group on a return to St. Louis. Although Lewis and Clark had travelled this way previously, many of their specimens had been lost. Therefore, many of the plants collected by Nuttall on this trip were unknown to science. The imminent war between Britain and America caused him to return to London via New Orleans. In London he spent time organising his large plant collection and discussing his experiences with other scientists.
Return to the US after the [War of 1812]; activities and major works (1815-1841)
In 1815, he returned to America and after spending some more time collecting published The Genera of North American Plants. From 1818 to 1820, he travelled along the Arkansas and Red Rivers, returning to Philadelphia and publishing his Journal of Travels into the Arkansas Territory during the year 1819. He was elected an Associate Fellow of the American Academy of Arts and Sciences in 1823. In 1825, he became curator of the botanical gardens at Harvard University. He published his Manual of the Ornithology of the United States and of Canada. In 1834, he resigned his post and set off west again on an expedition led by Nathaniel Jarvis Wyeth, this time accompanied by the naturalist John Kirk Townsend. They travelled through Kansas, Wyoming, and Utah, and then down the Snake River to the Columbia. Nuttall then sailed across the Pacific Ocean to the Hawaiian Islands in December. He returned in the spring of 1835 and spent the next year botanizing in the Pacific Northwest, an area already covered by David Douglas. On the Pacific coast, Nuttall heard of the ship Alert leaving San Diego in May 1836, bound for Boston. It is here that he miraculously encounters Richard Henry Dana Jr., a former student of his at Harvard who had set sail from Boston on a two-year voyage to the California coast at about the same time Nuttall had begun his expedition. Dana writes in his memoir, Two Years Before the Mast, of his amazement at seeing his old professor "strolling about San Diego beach, in a sailor's pea jacket, with a wide straw hat, and barefooted, with his trousers rolled up to his knees, picking up stones and shells." Nuttall was taken on the Alert as a passenger along with many of his flora and fauna specimens, which he brought back to Boston to be cataloged and preserved for posterity. Dana writes that though the professor spent much of the voyage in his cabin, he had some occasions to speak with Nuttall about his botanizing while Dana was at the helm of the ship "on a calm night" and was amused to hear his fellow shipmates refer to Nuttall as "Old Curious" for all the curiosities he conveyed on board. Once around the Horn, some of the sights on the trip through the South Atlantic prompted Nuttall to emerge from his quarters: upon sighting Isla de los Estados off the tip of Cape Horn, Nuttall told the Captain of the Alert that he would have liked to explore that place; and Nuttall also enjoyed the sight of dolphins swimming near the ship. From 1836 until 1841, Nuttall worked at the Academy of Natural Sciences in Philadelphia. During this time he made contributions to the Flora of North America being prepared by Asa Gray and John Torrey. The death of his uncle then required Nuttall to return to England. By terms of his uncle's will, to inherit the property, Nuttall had to remain in England for nine months of each year. His North American Sylva: Trees not described by F. A. Michaux, which was the first book to include all the trees of North America, was finished just before he left the US in December 1841.
Later
From 1842 until his death in 1859 Nuttall lived at Nutgrove Hall in St Helens, Lancashire, built by printer Jonas Nuttall in 1810. Nuttall is buried at Christ Church in the nearby village of Eccleston.
