Sometime in a dystopian future, World War III with Afghanistan breaks out. An incurable biological weapon called the "Y-bomb", which targets the male Y-chromosome, is used and results in the eventual deaths of 97% of the world's men. Feeling that they are better off without men, the planet's women decide to outlaw men because they were too violent. Years later, scientist Hope Chayse, fearing for the future of the species, conducts a cloning experiment to produce a new male, Adam, geneticallyenhanced to mature from baby to adult in weeks and to refrain from violence. When Adam reaches maturity, he soon finds himself on the run from the FBI, and hiding out with small rebel bands of the last surviving men on Earth.
End
The house Adam and Hope are hiding in is burnt to the ground. Kara gives Hope her car and tells her to run away. She makes up a story about the bodies in the house being Hope and Adam's, while Doe escaped in her car. Three months later, Esther visits Hope, now working as a waitress in Virginia. Esther tells her that the test was positive—-Hope is pregnant with a son, since she and Adam had sexthe night before he died.
Main characters
Hope Chayse - A CTUgraduate student in Genetic Engineering who invented Adam, initially hoping to satisfy her heterosexual desire. She used genetic engineering, eliminating the genes connected to violence and aggression. Her product, Adam, is a "new type of man" that has no tendency of violence.
Adam - A man created by genetic engineering who reaches full maturity in 33 days and stops aging. He escapes from Hope to explore "the city" by himself only to find out that he is in a world that abhors men. He meets a teenage girl, who takes him to her sister Lilah, a cross-dressed pimp. Lilah tricks him by taking him to Mother May, owner of a high class brothel where she employs a number of older surviving men.
Agent Kara Hastings - An FBI agent who is determined to capture Adam and restore a violence- and man-free society. She is under the supervision of Director Elizabeth Riggs played by, who is running for President. Once, during a raid of Mother May's brothel, Hastings finds Riggs is a customer there. She is persuaded to make a deal with Hope to bring Adam back safe, so he can be presented at a scientific conference.
Esther Hope's professor, who opposes the idea of engineering a man. She eventually helps Hope to cure Adam of the Y-chromosome plague, injected into him by Riggs.
John Doe - Leader of the Reclaimers, a small group of old men living in a deserted football field who hope to reclaim the government one day. He blames women for the Y-bomb, made to annihilate men. Doe holds Adam hostage in exchange for women, hoping that they will let his men reproduce. However, when Hope, Kara and Esther try to use Doe's blood to cure Adam, Doe takes Hope hostage and tries to rape her. Adam, although sick, picks up a gun and points it at him. Doe claims Adam isn't "man enough" to shoot, but he does so since he can't let anyone hurt Hope.
Reception
The Last Man on Planet Earth was parodied in "", an episode of .
