God lives in an apartment in Brussels which he shares with his meek wife and his 10-year-old daughter Ea, to whom he is emotionally and physically abusive. God is a grumpy sadist who created humankind specifically to have something to torment. He manipulates reality via a personal computer which he forbids his family from accessing. One day, Ea sneaks into his office and discovers how He has been mistreating humans. This enrages God who then whips Ea with his belt. Ea decides to rebel against her father. She steals the key to His office and accesses the scheduled dates of death of every human in the world and releases the information to them via their portable telephones. Everyone with a cell phone receives a text message informing them exactly when they will die. Ea then locks God's computer and escapes from the apartment through a washing machine which provides a tunnel to the outside world. Wandering the streets of Brussels, Ea decides to follow in the footsteps of her brother Jesus and write a Brand New Testament as her contribution to the human race. She selects six apostles to narrate their life stories. She first enlists a homeless man, Victor, to be her scribe, since she cannot write well. The first apostle is a reclusive woman who lost her left arm in an accident and feels nobody will love her. The second is a man who hates his work and his life, who has decided to never move from a bench in the park now that he knows the date of his death. Ea translates to allow him to converse with a bird. This induces him to follow a flock of birds to the North Pole. The third apostle is a sexually frustrated man who is awkward with women and remains lovesick for a German girl he met once as a boy. With Ea's encouragement, he becomes a voice actor for porn movies, where he encounters and establishes a relationship with his lifelong fixation. The fourth apostle is a man who is fascinated with death and killing. He purchases a rifle and shoots people knowing that, since all death dates are already predetermined, they can not be his responsibility. Ea prods him to shoot a woman, the first apostle. He hits her in her prosthetic arm. Believing this to be a divine signal, he courts the woman and they establish a relationship, and he learns to embrace life instead of death. The fifth apostle is an elderly woman trapped in a loveless marriage, especially now that her husband knows he will outlive her by many years. Ea persuades her to cheat on her husband. She has sex with a young male prostitute, and then forms a love relationship with a gorilla. The gorilla scares her husband away, to her delight. The sixth apostle is a sickly boy who, when he discovered he had only days left to live, decided to live them as a girl. Ea encourages him to live each day as the equivalent of one month. God is horrified when he discovers what Ea has done and that he can no longer torment humans. Locked out of his computer, He is powerless. He leaves the apartment using the chute in the laundry room, and in the real world He suffers all the mistreatment and frustrations He created for mankind. He is assaulted by everyone He meets. He discovers to his horror that the tunnel to his apartment has disappeared and He is trapped on Earth powerless and alone. He takes shelter in a church, where his outrageous criticism of his son Jesus Christ provokes a charitable priest into beating him senseless and eventually deporting him to Uzbekistan with a group of illegal immigrants. Ea and her apostles go to the seaside where hundreds of people have gathered to spend the last hours of their lives. An airplane, which happens to be carrying God under police escort, falls out of the sky and threatens to crash onto the beach and kill everyone. At the last moment, however, God's wife realizes that the number of apostles has grown to 18, her favorite number, explores her husband's work space, unwittingly restarts his computer, and begins to configure a new life for mankind. She deletes the messages that notified people of their death date. The airplane regains altitude and a new creation is born under a flower-filled sky. Victor publishes the Brand New Testament which becomes a bestseller and catapults him out of hopeless poverty into a whole new life of fame and fortune. God reaches Uzbekistan where he works on an assembly line manufacturing washing machines. He keeps on searching without success for the washing machine with the escape hatch that will take him back to his apartment.
The Brand New Testament received generally favorable reviews from film critics. On Rotten Tomatoes, the film holds an approval rating of 82%, based on 74 reviews with an average rating of 7/10. The website's critical consensus reads, "The Brand New Testament takes a surreal, subversive, and funny look at Biblical themes through a modern — and refreshingly original — lens." At Metacritic, the film received an average score of 70 out of 100, based on 17 reviews from mainstream critics, indicating "generally favorable reviews".
