Talopram


Talopram, also known as phthalapromine, is a selective norepinephrine reuptake inhibitor which was researched for the management of depression in the 1960s and 1970s but was never commercialized. Along with talsupram, talopram is structurally related to the selective serotonin reuptake inhibitor citalopram, as well as to melitracen:

Synthesis

An unexpected/fortuitous rearrangement product in the synthesis of litracen is what lead to talopram.