Before the Hellenistic era, the goddessIsis Lactans was worshipped in Tafas, as evidenced by the discovery of statuette of her in the town. During the Roman era in Syria, a Jewish community existed in Tafas. Several funerary stelae, the earliest dating to 64 BCE, were found in Tafas. A bronze patera from the Roman era was also found, but it was later stolen from the Mohammedan Museum of Damascus.
In 1596, Tafas appeared in Ottoman tax registers as being in the nahiya of Bani Malik al-Asraf in the Qada Hawran. It had a population of 73 households and 40 bachelors, all Muslim. The villagers paid a fixed tax rate of 40% on wheat, barley, summer crops , goats and beehives , in addition to occasional revenues. In 1810, Tafas was "ruined" by Wahhabi tribesmen, according to Johann Ludwig Burckhardt. The first elementary school in the village was built in 1865. In the 1880s, Tafas was described as a moderate-sized village of around 100 stone-built houses inhabited by around 250 Muslims. Some of the houses were in ruins and not inhabited. There was an active Friday mosque. A decade later, it was described as having 90 houses and 400 inhabitants. In 1918, the town was the site of the infamous Tafas massacre perpetrated by the retreating Ottoman Army during World War I. According to T. E. Lawrence, on 27 September retreating Turkish troops had slaughtered many of the town's inhabitants, including women and children. In retaliation for the massacre, Lawrence's troops attacked the retreating Turkish columns and ordered all captured prisoners, around 250, including German and Austrian soldiers, to be executed.
There was a square tower, known as a medany, with an elevation of 50 feet and a width of 10 feet with a square-shaped base. It consisted of two floors, each having a window. The tower was attached to a Friday mosque measuring 46 feet by 41 feet. On its western side were terrace-like steps leading to the mosque's roof, which was supported by three rows of columns, each row consisting of four columns, the shafts of which had a height of 5 feet. The entire column stood at 9 feet 5 inches. In each row, the two center columns stood out independently while the first and last columns were built into the wall. Together with the arches the total height of the mosque's interior space was nearly 16 feet. The mosque was largely constructed sometime during the Islamic era, although there were some architectural elements dating to the Roman or Byzantine era.
