TREM1


Triggering receptor expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM1 gene.

Function

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors, Fc receptors, CD14 and Toll-like receptors, and cytokine receptors. Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating or inhibitory functions. In granulocyte cells, TREM1 is activated by C/EBPε independently from inflammatory response.

Model organisms

s have been used in the study of TREM1 function. A conditional knockout mouse line called Trem1tm1Vlcg was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping