Succinylation
Succinylation is a posttranslational modification where a succinyl group is added to a cysteine residue of a protein molecule. This modification is found in many proteins, including histones. The potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 and introduces a relatively large structural moiety, bigger than acetylation or methylation, it is expected to lead to more significant changes in protein structure and function.
By analogy to acetylation, it has been suggested that succinyl-CoA is the cofactor of enzyme-mediated lysine succinylation.
