Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate
Succinimidyl 4-cyclohexane-1-carboxylate is a heterobifunctional amine-to-sulfhydryl crosslinker, which contains two reactive groups at opposite ends: N-hydroxysuccinimide-ester and maleimide, reactive with amines and thiols respectively. SMCC is often used in bioconjugation to link proteins with other functional entities. For example, a targeted anticancer agent – trastuzumab emtansine – is prepared using SMCC reagent.
