Streptazolin


Streptazolin is an antibiotic and antifungal substance isolated in 1981 from Streptomyces viridochromogenes.
Because of its polymerisation tendency, it is not suitable for therapeutic use. 1,4-reduction of the conjugated diene gives dihydrostreptazolin which is stable, but has very limited antimicrobial properties.
The first total synthesis of streptazolin was achieved in 1985 with the aid of a modified Ferrier rearrangement.