Born in Varese, Garzelli started out as being a domestique for Marco Pantani but proved in 2000 that he deserved much more. When "The Pirate" lacked form in the beginning of the 2000 Giro, Garzelli was left free of all team duties for, and was able to fight and win his own battle in the Giro. In the final time-trial stage Garzelli took the race leadership away from Casagrande, who was suffering an inflamed sciatic nerve. Casagrande was devastated, and Garzelli dedicated his win to Pantani. He was a versatile rider with qualities that included decent sprinting, decent time trials and some good skills in the mountains. Without being a great attacker, Garzelli was very constant and, on a good day, he could go with the best climbers. After his win of the 2000 Giro d'Italia he was recruited by the Italian super-team in 2001, aiming to repeat his 2000 Giro success. The start of the season showed promise, with Garzelli being a key player in teammate Paolo Bettini's win in Liège–Bastogne–Liège, with Garzelli himself finishing second. The finale of the race saw Bettini and Garzelli make tactical moves to benefit from each other's aggressions and saw them finish the race with a comfortable margin to decide the win amongst themselves. However, Garzelli was caught in the 2002 doping scandal in the Giro d'Italia, and was forced out of the race. Many believe that the circumstances of his suspension prompted the Mapei boss Giorgio Squinzi to terminate his sponsorship of the team at the end of the year. "The exclusion of Garzelli, who tested positive for a masking agent, wasn't a normal thing. At the start nothing was found. Later, as soon as he won a stage, a forbidden substance came out all of a sudden. That's bizarre," said Squinzi in an interview. Belgian champion Freddy Maertens cast doubt on whether Garzelli was guilty of choosing to doping, likening the incident to the 1974 world championships, in which Martaens was deliberately sabotaged by the soigneur of his rival Eddy Merckx. Garzelli was able to mount a comeback for the 2003 Giro d'Italia and was able to challenge eventual winner Gilberto Simoni in the race. In December 2012, Garzelli signed a one-year contract with the team for the 2013 season, and retired thereafter. He now works for RAI the Italian national broadcaster as a summariser on the Cycling programmes covered by RAIsport such as the Giro d'Italia and Tour de France.
