SprX small RNA
In molecular biology the small pathogenicity island RNA X gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus. SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections. In this study the authors identified a SprX target, stage V sporulation protein G. By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.
