Blois was an Alderman of Dunwich from 1685 and appointed to the commission of the peace for Suffolk in 1685. On 15 April 1686 he was created Baronet Blois, of Grundisburgh and Cockfield Hall. In March 1688, he was appointed a Commissioner for inquiry into recusancy fines for Cambridgeshire, Norfolk and Suffolk. He was removed from the Dunwich corporation in June 1688 but was restored in November 1688 and was Commissioner of assessment for Suffolk from 1689 to 1690, and for Dunwich and Ipswich in 1689. He was returned as a Tory Member of Parliament for Ipswich in a by-election on 28 May 1689. A very active Member of the Convention Parliament, he was appointed to 36 committees. He was returned in a contest as MP for Ipswich at the 1690 English general election and as a Court Tory continued a high level of activity in Parliament. In 1693 Blois succeeded his aunt Mary Brooke to the Yoxford estate, which gave him an electoral interest at Dunwich. His wife Mary died in 1693 and he married as his second wife, by licence dated 18 April 1694, Anne Hawtrey, daughter of Ralph Hawtrey, MP of Eastcote House, Ruislip, Middlesex. He was defeated at Ipswich at the 1695 English general election and did not stand in 1698. Blois was returned as MP for Dunwich at a by-election on 29 January 1700 and followed up with a return unopposed at the first general election of 1701. He was blacklisted for opposing the preparations for war with France. On his return unopposed at the second general election of 1701, he was classed with the Tories and voted on 26 February1702 for the vindication of the impeachment proceedings against William III's ministers. He was returned unopposed at the 1702 and was active in Parliament with local matters. He voted for the Tack on 28 November 1704. At the 1705 English general election he was again unopposed at Dunwich and voted against the Court candidate for Speaker on 25 October 1705. There was a contest at Dunwich at the 1708 British general election and he was elected in the poll but was unseated on petition on 5 February 1709. He did not stand for Parliament again. He was bailiff of Dunwich in 1708 and from 1711 to 1712 and probably a portman in 1709.
Death and legacy
Blois died on 9 April 1738 and was buried at Grundisburgh. By his first wife Mary, he had three sons, of whom two predeceased him, and a daughter. He was succeeded in the baronetcy by his surviving son Charles. By his second wife Anne, he had two sons of whom one predeceased him and a daughter Anne. Their son Ralph also succeeded to the baronetcy. His sister Mary was the third wife of Sir Nevill Catlin and then wife of Sir Charles Turner, 1st Baronet..