Sigmavirus


Sigmavirus is a genus of viruses in the family Rhabdoviridae, order Mononegavirales. Sigmaviruses naturally infect dipterans.

Taxonomy

Table legend: "*" denotes type species.

Discovery

Drosophila melanogaster sigmavirus was discovered by a group of French researchers in 1937 after they observed certain fly lines became paralysed and died on exposure to carbon dioxide. They found the carbon dioxide sensitivity was caused by an infectious agent which they named sigma, and was later found to be a rhabdovirus. More recently new sigmaviruses have been discovered in diptera of six species ; five in species of Drosophila and one in the family Muscidae.

Transmission

DMelSV, DAffSV and DObsSV are transmitted vertically by both drosophila parents suggesting sigmaviruses may be a clade of vertically transmitted viruses. This unusual mode of biparental vertical transmission allows the virus to spread through host populations even if it reduces the fitness of infected hosts.

Host resistance

In Drosophila melanogaster resistance alleles in the genes refp and CHKov 1 and 2 and have been identified that explain a large amount of the genetic variation in susceptibility to DMelSV infection.

Structure

Sigmavirions are enveloped, with bullet shaped geometries. Sigmavirus genomes are linear, around 12.6 kb in length. The genome codes for 6 proteins.
GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
SigmavirusBullet-shapedEnvelopedLinear

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Drosophilae serve as the natural host.
GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
SigmavirusDrosophila-Clathrin-mediated endocytosisBuddingCytoplasmCytoplasmUnknown