Sialic acid acetylesterase


Sialic acid acetylesterase is an enzyme that produces 9-O acetylated sialic acid e.g. in mammals. It down-regulates B lymphocyte antigen receptor signaling, and is required for immunological tolerance e.g. in mice.
Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.