Ogino graduated from University of Tokyo School of Medicine in 1993, and from University of Tokyo Graduate School of Medicinein 2001. He underwent internship at U.S. Naval Hospital Okinawa in Japan from 1994 to 1995. After coming to the United States, Ogino underwent residency training in anatomic pathology and clinical pathology at Allegheny General Hospital from 1995 to 1997, and at Case Western Reserve University/University Hospitals Case Medical Center from 1997 to 1999. He underwent fellowship training in molecular pathology at University of PennsylvaniaMedical Center from 1999 to 2000. After postdoctoral fellowship at University of Pennsylvania, he joined Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School as Instructor in Pathology in 2001. Ogino was promoted to Assistant Professor in 2004, to Associate Professor in 2008, and to Professor of the institutes in 2015. He received a Master of Science in Epidemiology degree from Harvard T.H. Chan School of Public Health in 2010, and then subsequently obtained a secondary faculty appointment in 2012, promoted to Professor at that school in 2015. Ogino became Chief of Program in MPE Molecular Pathological Epidemiology at Brigham and Women’s Hospital in 2016, and an associate member of Broad Institute of MIT and Harvard in 2017.
Ogino proposed that research into molecular pathology with epidemiologic settings should be regarded as a distinct field, and used the term “Molecular Pathological Epidemiology ” in 2010. Since his proposal, the MPE concept and paradigm have been in widespread use, and MPE has been a subject of international conferences such as American Association for Cancer Research, Society for Epidemiologic Research, and the American Society of Preventive Oncology. The MPE approach aims to elucidate etiology of disease at molecular, individual, and population levels, applying molecular pathology to epidemiology. Utilizing tissue pathology resource and data within existing epidemiology studies, he has been publishing a large number of original articles proving the interrelationship between exposure to risk factors and molecular pathologic signature of disease including some of influential papers in the field, as well as papers which have developed the concepts of MPE. Ogino’s discoveries with the MPE approach include the interaction between aspirin use and PIK3CA mutation in colorectal cancer, and the interaction between endoscopy screening and post-colonoscopy colorectal cancer with CIMP and microsatellite instability MSI. He initiated the International Molecular Pathological Epidemiology Meeting Series in 2013, and has been serving as the conference chairperson. Its second and third meetings were held in Boston, in December 2014, and May 2016, respectively. Ogino employed the MPE concept for proposing a paradigm shift in colorectal cancer research. His proposal for a transition from the two-colon concept to the colorectal continuum model was supported by an observed linear relationship between the location on the colon and Microsatellite instability, CpG island methylator phenotype and BRAF mutation frequency from the database analyses of over 1,400 colorectal cancer cases. This colorectal continuum model has been supported by others. Ogino has introduced several new paradigms and research frameworks, including “the GWAS-MPE approach”, “the unique tumor principal”, “the unique disease principle”, “the etiologic field effect model”, "the integrative lifecourse epidemiology - MPE model", “the pharmaco-MPE model” and “the immuno-MPE model”, all of which are related to the field of MPE.
