Sara Snogerup Linse


Sara Snogerup Linse is a Swedish Professor of Biochemistry at Lund University. Her research considers the molecular mechanisms of protein self-assembly in Alzheimer's disease. She serves as Chair of the Committee for the Nobel Prize in Chemistry. She was awarded the 2019 European Molecular Biology Organization Women in Science Award.

Early life and education

Linse grew up in the Oskarshamn Municipality. Her parents are both botanists. She was thirteen years old when she first learned about proteins, and her high school teachers told her that there were still mysteries in establishing their structure – function properties. She studied chemical engineering at Lund University and Stanford University. She graduated in 1985 and started a doctorate at Lund University in physical chemistry. She then came across another challenge in biochemistry: the interaction of proteins with nanoparticles.

Research and career

Linse was appointed to the faculty at Lund University in 1993, where she was promoted to Professor in 2004. Her research considers the molecular basis of neurological and metabolic diseases.
When proteins spontaneously aggregate they can form fibrous clumps known as amyloids. Amyloid-beta peptides are associated with several neurological diseases, including Alzheimer's and Parkinson's disease. Linse has demonstrated that the process of nucleation and growth of amyloid-beta peptide occurs in two phases; first the amyloid fibrils form and then monomers nucleate on the surface. This second nucleation event gives rise to most of the neuronal toxicity. Linse was supported by the Knut and Alice Wallenberg Foundation to investigate the role of fat in protein self-assembly. Fat molecules are often present when aggregations are formed, but the majority of research considers how proteins attach to the cell membrane.
Her research makes use of a variety of analytical tools to study protein amyloid formation. In 2020 Linse and co-workers announced a mathematical model that could be used to describe the chemical reactions that are responsible for the fibroid aggregation associated with Alzheimer's disease.

Awards and honours

Her awards and honours include:
Her publications include:
Linse publishes children's books with her partner Kyrre Thalberg. These have included Draksommar, Kjetil och Jostein, Höst i Drakbergen, Prins Pralin åker buss, and Karnevalen i Brind. She is also 2018 World Masters Orienteering Champion.