In 1995, Keeble was selected to stand for the Labour Party in Northampton North through an all-women shortlist. Keeble served on the Agriculture Select Committee, and became Parliamentary Private Secretary to Rt. Hon Hilary Armstrong in 1999. After the 2001 general election she was appointed Parliamentary Under Secretary of State at the Department of Transport, Local Government and the Regions, where her responsibilities included planning, regeneration, housing and local transport. She chaired the taskforce on parks and urban green spaces. In 2002, she moved to the Department for International Development. In 2003, she left the frontbench. From 2005, she was a member of the Treasury Select Committee. Keeble introduced a private members bill to introduce the offence of causing death by careless driving: the measure was later accepted by the Government and introduced in the Road Safety Act 2006. She also introduced ten-minute rule bills on flooding, and a bill on minimum pricing for alcohol. Keeble was involved in the 2009 United KingdomParliamentary Expenses scandal claiming £4,112 for windows at her Northampton house under the second home allowance, £3,072 for a new boiler and £950 for essential maintenance on the bathroom at her Northampton home. At the 2010 general election, Keeble lost her Northampton North seat by 1,937 votes to the Conservative Party candidate Michael Ellis, a swing of 6.9% from the previous election. At the 2019 United Kingdom general election Keeble failed to regain her Northampton North seat. The Conservative candidate Michael Ellis increased his majority to 5,507, a swing of 6% from the previous election, to hold his seat in Northampton North. Keeble has stood as the Labour candidate at every general election between 1997 and 2019.
Personal life
Keeble married Andrew Hilary Porter on 9 June 1990 in Camberwell; the couple have a son and daughter together. She is an honorary fellow of South Bank University. Her sister, Jane Mahoney, and her brother-in law Anthony; were killed on 12 July 1998 near Darwin in Australia. A Hells Angel motorcyclist had ploughed into them whilst they were waiting by the roadside after Anthony changed a wheel. The Hell's Angel carried on driving and failed to report the accident. After the accident, her father, Sir Curtis Keeble, the former British ambassador to the Soviet Union from 1978–82 and governor of the BBC, had a heart attack.