SYT1


Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.

Function

are integral membrane proteins of synaptic vesicles thought to serve as sensors for calcium ions in the process of vesicular trafficking and exocytosis. Calcium ion binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse.
SYT1 is the master switch responsible for allowing the human brain to release neurotransmitters. SYT1 senses calcium ion concentrations as low as 10 ppm and subsequently signals the SNARE complex to open fusion pores.

Interactions

SYT1 has been shown to interact with SNAP-25, STX1A and S100A13.