SUV39H1
Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.Function
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.Interactions
SUV39H1 has been shown to interact with:
- CBX1,
- CBX5,
- DNMT3A,
- HDAC1,
- HDAC3,
- HDAC9,
- Histone deacetylase 2,
- MBD1,
- RUNX1,
- Retinoblastoma protein, and
- SBF1.
- PIN1
