STAG3 (gene)


Stromal antigen 3 is a protein that in humans is encoded by the STAG3 gene. STAG3 protein is a component of a cohesin complex that regulates the separation of sister chromatids specifically during meiosis. STAG3 appears to participate in sister-chromatid cohesion throughout the meiotic process in human oocytes.
A homozygous 1-bp deletion inducing a frameshift mutation in STAG3 causes premature ovarian failure.