SPR domain
In molecular biology the SPR domain is a protein domain found in the Sprouty and Spread proteins. These have been identified as inhibitors of the Ras/mitogen-activated protein kinase cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain. It has been found to be a PtdInsP2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential. It also mediates homodimer formation of these proteins.
The SPR domain can occur in association with the WH1 domain in the Spread proteins.Examples
Human genes encoding protein containing the SPR domain include:
