SOCS6
Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor, also known as suppressor of cytokine signaling or STAT-induced STAT inhibitor protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia and erythroleukemia cell lines.
