List of highways numbered 81

International

• Asian Highway 81
• European route E81

  Australia

• Escort Way
• Mulligan Highway and Peninsula Developmental Road - Queensland State Route 81

  Canada

• Newfoundland and Labrador Route 81

  India

• National Highway 81

  Korea, South

• National Route 81

  Mexico

• Mexican Federal Highway 81

  United States

• Interstate 81
• * Interstate 81E
• * Interstate 81S
• U.S. Route 81
• Alabama State Route 81
• Arizona State Route 81
• Arkansas Highway 81
• California State Route 81
• Connecticut Route 81
• Florida State Road 81
• * County Road 81A
• Georgia State Route 81
• Idaho State Highway 81
• Illinois Route 81
• Iowa Highway 81
• Kentucky Route 81
• Louisiana Highway 81
• * Louisiana State Route 81
• Maryland Route 81
• Massachusetts Route 81
• M-81
• Minnesota:
• * Minnesota State Highway 81
• * Minnesota State Highway 81
• Missouri Route 81
• Montana Highway 81
• Nebraska Highway 81
• Nevada State Route 81
• New Jersey Route 81
• * County Route 81
• New Mexico State Road 81
• New York State Route 81
• * County Route 81A
• **County Route 81C
• * County Route 81
• * County Route 81
• * County Route 81
• * County Route 81
• * County Route 81
• * County Route 81
• * County Route 81
• * County Route 81
• * County Route 81
• North Carolina Highway 81
• Country Road 81
• Ohio State Route 81
• Oklahoma State Highway 81A
• Pennsylvania Route 81
• Rhode Island Route 81
• South Carolina Highway 81
• South Dakota Highway 81
• Tennessee State Route 81
• Texas State Highway 81
• * Texas State Highway Loop 81
• * Farm to Market Road 81
• Utah State Route 81
• Virginia State Route 81
• West Virginia Route 81
• * West Virginia Route 81
• Wisconsin Highway 81

• U.S. Virgin Islands Highway 81