Ru360
Ru360 is an oxo-bridged dinuclear ruthenium ammine complex with an absorption spectrum maximum at 360 nm. It is an analog of ruthenium red, a well-known effective inhibitor of the mitochondrial calcium uniporter.
Ru360 was discovered after scientists found that commercial preparations of ruthenium red were often less than 20% pure, and that the crude mixture produced a stronger inhibition than the purified product. This component was later isolated and identified as Ru360.
Since Ru360 inhibits the flow of calcium into mitochondria, which can prevent the opening of the mitochondrial permeability transition pore, it has been investigated as a therapeutic treatment for stroke and heart attack.
