Rostral neuropore

Failure to close

• Failure of closure of the anterior neuropore during embryogenesis will lead to anencephaly, the failure of the brain and skull to develop. In less severe situations it may lead to different forms of encephalocele. There are three forms of cranium bifidum: mengocele, meningo-encephalocele and meningohydro-encephalocele. In which respectively protrude the meninges, the meninges and brain tissue and lastly meninges, brain tissue and cranial ventricles.
• Failure of closure of the posterior neuropore during embryogenesis will lead to spina bifida. this condition is always marked by a local lack of osteogenesis, or bone growth. The reason is that the correct differentiation and placement of underlying tissues induce the osteogenesis, even small flaws in the underlying tissues can lead to a problem in the formation of the spine. Occasionally spina bifida is accompanied by a protrusion of the meninges and cerebrospinal fluid or protrusion of meninges, cerebrospinal fluid and nerve tissue.