Louis played football at Miami Beach Senior High School, where he played at quarterback, running back, wide receiver, tight end, linebacker, and safety. Excellent at all positions, his best performances came at a running back and receiver. In his senior year, he had 14 offensive touchdowns and 60 defensive tackles. ESPN ranked him the 21st best high school player in the nation in 2012. Louis wavered in the college draft. He initially committed to Auburn University, then broke the commitment and committed to Florida State University. He broke that commitment as well, and finally agreed to play for Auburn. Louis "was not nearly as productive" in college as in high school. Although he often started games, he was never a full-time starter. His most memorable play was a touchdown reception against the Georgia Bulldogs in 2013, known as the "Prayer at Jordan-Hare". The catch enabled the Tigers to win their division, enter the post-season, and make it into a national championship game. He led the Tigers in receptions and touchdowns as a senior. Louis ended his career at Auburn in 2015 with 98 receptions out of 117 touches for and eight touchdowns. Louis' collegiate career was also plagued by dropped passes, and he had six fumbles. He was nominated his senior year for an ESPY Award.
The Cleveland Browns drafted Louis in the fourth round, 114th overall, in the 2016 NFL Draft. On May 31, he signed a four-year contract worth about $2.9 million, which included a signing bonus worth about $568,000. Louis incurred a hamstring injury during practice on August 13, keeping him out of the rest of the preseason. In 2018, Louis changed his number from #80 to #15, to make way for Jarvis Landry, who was traded previously from the Miami Dolphins. The Browns announced on July 25, 2018 that Louis would miss the entire 2018 season with a neck injury. Louis was waived by the Browns on April 1, 2019.
Miami Dolphins
On April 8, 2019, Louis signed with the Miami Dolphins. On May 16, 2019 the Dolphins placed Louis on injured reserve, ending his 2019 season. On February 4, 2020, Louis was re-signed to a one-year, $660,000 contract. The Dolphins released him on July 25, 2020.
