Lockette was signed by the Seattle Seahawks as an undrafted free agent following the end of the NFL lockout in 2011. He was released on September 3, and re-signed to the Seahawks' practice squad the following day. On December 14, 2011, Lockette was promoted to active 53-man Seattle Seahawks' roster. Lockette made a critical 44-yard reception in a close loss to division rival San Francisco 49ers on December 24, 2011, as well as a 61-yard touchdown grab in an overtime loss to another rival, the Arizona Cardinals, on January 1, 2012. Lockette was cut during final roster cuts after the 2012 preseason. He was signed to the practice squad, but was released by the team on September 18.
San Francisco 49ers
Lockette was signed to the San Francisco 49ers practice squad on September 24, 2012. On August 22, 2013, he was released by the 49ers to make room on the roster for newly signed quarterback Seneca Wallace.
On September 1, 2013, Lockette was signed by the Chicago Bears to the practice squad. He was waived by the team on October 21.
Seattle Seahawks (second stint)
Lockette returned to the Seahawks on October 22, 2013. He became a special teams player during his second stint with the Seattle Seahawks. Lockette won Super Bowl XLVIII with the Seahawks on February 2, 2014, where he had one catch for 19 yards in the 43–8 win over the Denver Broncos. In Super Bowl XLIX, Lockette had 3 catches for 59 yards, but the Seahawks lost 28–24 to the New England Patriots. He was the intended receiver on the Seahawks last offensive play as it was intercepted by Malcolm Butler. Seattle's offensive coordinator Darrell Bevell said afterwards in a post-game interview that Lockette "could have done a better job staying strong on the ball." On March 9, 2015, the Seahawks stated they would not tender Lockette, thus making him an unrestricted free agent; however, he eventually re-signed. While on punt coverage during a November 1, 2015 road game against the Dallas Cowboys, Lockette was concussed after a clean hit by Cowboys safety Jeff Heath”Lockette even stated that being a clean hit”. As Lockette was carted off the field, he raised his hand and gestured in the shape of an 'L', a representation of Seattle's "Legion of Boom". The next day, the Seahawks announced Lockette had suffered neck ligament damage that required season-ending surgery.
Retirement
Lockette announced his retirement on May 12, 2016, citing the 2015 injury as "50% of the reason." Lockette now works as an advocate for spinal cord injury research with the Seattle Science Foundation.
