She has been a member of the team of lawyers for defense of political prisoners since 2001. In the same year, Razan was one of the founders of the Human Rights Association in Syria. In 2005, Razan Zaitouneh established SHRIL, through which she continues to report about human rights violations in Syria. From 2005 through to her 2013 disappearance, Razan Zaitouneh was an active member of the Committee to Support Families of Political Prisoners in Syria. Syrian State television aired announcement that Razan Zaitouneh was a foreign agent on 23 March 2011, after which she went into hiding while continuing her legal and human rights work, in order to avoid being arrested. Zaitouneh founded the Violations Documentation Center in Syria in April 2011 to document human rights violations and abuses in the country by all sides. She also contributed to human rights violations reports circulated by the Local Coordination Committees of Syria, of which she was one of the founders. Her husband, Wael Hamadeh was arrested on 12 May 2011. His brother 'Abd al-Rahman Hammada was also arrested. Wael Hamadeh was questioned in prison about his wife's human rights work, then Wael Hamadeh released on 1 August 2011. On 27 October 2011, she was awarded the 2011 Sakharov Prize for Freedom of thought, jointly with four other Arabs. She was previously awarded the Anna Politkovskaya Award by Reach All Women in War. In 2013 Razan Zaitouneh was granted the International Women of Courage Award.
2013 disappearance
Pro-opposition websites reported that on 9 December 2013 Zaitouneh had been kidnapped along with her husband, Wael Hamadeh, and two colleagues, Samira Khalil and Nazem Hammadi, in the opposition-held town of Douma to the north of Damascus. As of December 2015, their whereabouts were still unknown and the identity of the kidnappers uncertain, although it was suspected that the Islamist Salafi rebel group Army of Islam was responsible. , Associated Press was unaware of significant evidence for Zaitouneh's fate. AP stated clues suggesting that Jaysh al-Islam had detained Zaitouneh and held her in Tawbeh Prison. Jaysh al-Islam denied the claim. One clue was graffiti seen by several witnesses on a prison cell wall stating, "I miss my mother — Razan Zaitouneh, 2016." Another clue was the use of one of the Violations Documentation Center computers, taken together with Zaitouneh in the December 2013 kidnapping, from a Jaysh al-Islam IP address at Tawbeh Prison. Another opposition activist, Mazen Darwish, stated that Zaitouneh was held by Jaysh al-Islam until early 2017. AP judged it likely that Zaitouneh had been killed. On 17 February 2020, one of the Syrian intelligence agencies declared that it had discovered a mass grave in al-Ub around the eastern Ghouta dictrict, containing around 70 bodies. One of them appeared to be that of Razan Zaitouneh.
