Muzyka co-founded BioWare, which was incorporated in 1995, with Greg Zeschuk and Augustine Yip, in the early 1990s after they earned their medical degrees at the University of Alberta. After selling BioWare to Electronic Arts in 2008, Muzyka became a general manager and vice president at EA in addition to his CEO role at BioWare, and subsequently was promoted to senior vice president and general manager of the BioWare label at EA. In addition to his project development role, Muzyka has also managed the financial, human resources, operations, marketing and legal business side of BioWare, and he completed his executive Masters in Business Administration program in 2001 at the Ivey School of Business, UWO. He completed his Medical Doctorate in 1992 from the University of Alberta, and subsequently obtained his specialization from the Canadian College of Family Physicians in 1994. Muzyka was named as one of Canada's "Top 40 under 40" in 2001, received Ernst and Young's Entrepreneur of the Year award in 2001, and the BDC Young Entrepreneur of the Year award in 1997. Muzyka also graduated from Old Scona Academic High School in Edmonton, Alberta, Canada where he took the International Baccalaureate program, finishing fourth worldwide and first in North America the year he graduated. Muzyka was inducted into the Academy of Interactive Arts and Sciences' Hall of Fame in 2011., received the Lifetime Achievement award from the International Game Developers Choice Awards in 2013, and was named as the 2017 Allard Chair in Business at MacEwan University. He was named into the Alberta Business Hall of Fame in 2018. On December 27, 2018, Muzyka was appointed to the Order of Canada. In 2019 Muzyka received the Rod Charko Service Award from the Venture Capital Association of Alberta for his service to the startup entrepreneurial community in the province of Alberta. Muzyka is an active member of the Young Presidents' Organization, and a Charter Member of the A100 since 2012. He also serves as the Founding Chair of the University of Alberta Venture Mentoring Service since fall 2013, a program intended to help develop, uplift and inspire University of Alberta student and alumni entrepreneurs by creating excellent mentorship experiences for both entrepreneurs and mentors. Muzyka served from 2014-2020 as a member of the University of Alberta Board of Governors, and as Chair of the Human Resources and Compensation Committee. He serves as a mentor in the Creative Destruction Lab. Muzyka was from 2001–2008 a board member of the Academy of Interactive Arts and Sciences. Muzyka served the Stollery Children's Hospital Foundation as a volunteer Director on their Board of Trustees from 2012 to late 2015. In October 2012 Muzyka announced on the BioWare website that he was retiring from the video game industry and that he is moving on to a 'third career chapter', mentoring and investing in entrepreneurs in technology, new media, medical innovation, and social entrepreneurs and impact investing. He announced his new company, Threshold Impact, in early 2013, to be focused on "sustainable, profitable impact investing". An avid poker player who plays in the WSOP and other events each year, Muzyka won the inaugural DICE poker tournament, in 2006 which featured a range of notable poker celebrities such as Scott Fischman, Chris Ferguson and Perry Friedman, playing heads-up with Mike Morhaime from Blizzard Entertainment at the final table. He also became the only player thus far to win the DICE tournament twice, when he chopped the final table with three other players for first place again in the 2010 DICE tournament. He competed in the 2008 WCPC CPT Main Event and chopped the final table with the final four players to take home the 2008 WCPC ring. He finished 374th of 7319 players in the 2010 Main Event of the WSOP.
BioWare projects credited with platforms and dates
At the Game Developers Choice Awards, on March 27, 2013, Muzyka was awarded the Lifetime Achievement Award. On December 27, 2018, Muzyka was appointed to the Order of Canada.