In, Liz started his first full professional season with the Frederick Keys, the highest of the Orioles' three Single-A teams. Liz began the season by striking out 33 batters in his first 15 innings pitched. Later in the year, he represented the Orioles on the World squad at the All-Star Futures Game. He also received a promotion to the Double-A Bowie Baysox; between the two teams, he struck out 149 batters in 133 innings before playing in the Dominican Winter League. However, he had difficulty with his control in the 2006 season, walking 75 batters. Baseball America named Liz the Orioles' fifth-best prospect going into the season, following Billy Rowell, Brandon Erbe, Nolan Reimold, and Pedro Beato. Liz returned to Bowie for the 2007 season and was selected for the Eastern League's All-Star Game. He no-hit the Harrisburg Senators on June 1. His no-hitter was the first nine-inning no-hitter ever pitched at Prince George's Stadium, which has been open since. On August 14, Liz took a no-hitter into the eighth inning against the Connecticut Defenders; he then allowed a single and a two-run home run, but struck out 14 batters in eight innings. For the 2007 season, Liz had an 11–4 record for the Baysox with a 3.22 ERA and 161 strikeouts in 137 innings pitched. In his 10 starts at the Baysox' Prince George's Stadium, he was 9–0 with a 2.02 ERA in 62 innings pitched. The Orioles recalled him from Bowie on August 24,, to make a start against the Minnesota Twins at Oriole Park at Camden Yards the following day. He allowed five runs, including a three-run home run to Torii Hunter, in six innings. He consistently threw 97–98 miles per hour, with one pitch clocked at 100. In 2008, he mostly played for the Norfolk Tides, the Orioles' Triple-A affiliate in Norfolk, Virginia.
On November 25, 2009, Liz was claimed off waivers by the San Diego Padres. He played the 2010 season with the Portland Beavers, Triple-A affiliate of the Padres and posted an 8–8 record with a 4.83 earned run average and 109 strikeouts. On January 5, 2011, Liz was released by the San Diego Padres.
LG Twins
On January 7, 2011, he signed with the LG Twins of the KBO League. Liz enjoyed a tenure of success in the KBO, leading the league in strikeouts in 2013 with 188. He would post a 26–38 record with a 3.51 ERA in 3 seasons with the Twins totalling 518 innings pitched.
On December 13, 2014, Liz signed a one-year Major League contract with the Pittsburgh Pirates for $1 million. Initially it was reported to be a two-year contract for $3 million. However, the deal was adjusted due to the Pirates being "uncomfortable" with Liz's physical results. On May 25, Liz was designated for assignment. He was re-added to the major league roster on September 1 and designated for assignment again on September 15.
On December 22, 2017, Liz signed a minor league contract with the Milwaukee Brewers. He was released on June 1, 2018.
Lamigo Monkeys
On February 1, 2019, Liz signed with the Lamigo Monkeys of the Chinese Professional Baseball League. On January 5, 2020, he re-signed with the team for the 2020 season. However, on February 9, Liz opted out of his contract for unspecified reasons, though he later clarified that it was due to a herniated disc in his back that he wanted to address.
Scouting report
Liz is known for his remarkably long arms; when he stands with his arms at his sides, his fingers reach below his knees. Liz uses a straight overhand pitching motion and throws his fastball consistently in the mid- to upper-90s and has been clocked at 99 mph. His other pitches include an overhand curveball, a sinker, a slider, and two variations of a changeup. Early in his professional career, Liz received attention because of a clicking sound which is sometimes loud enough to be heard in the stands and occurs whenever he throws a pitch. Some have thought it to be his thumb clicking against his index finger. Orioles head athletic trainer Richie Bancells discovered that Liz's scapula caused the clicking; although rare, this condition does not hurt his pitching career. To treat this condition, Liz has been doing an exercise program to strengthen the muscles around his collarbone.
