REG3G


Regenerating islet-derived protein 3 gamma is a protein that in humans is encoded by the REG3G gene.
Intestinal paneth cells produce REG3G via stimulation of toll-like receptors by pathogen-associated molecular patterns. REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.