Mikell attended the Boise State University, and played for the Boise State Broncos football team. He finished his career ranked second on the school's all-time tackles list.
Professional career
Philadelphia Eagles
After being undrafted in the 2003 NFL Draft, Mikell signed with the Philadelphia Eagles. He has posted a team-leading 108 special teams tackles since joining the Eagles, including a career-high 35 in 2006. As such, Mikell has been voted by his teammates as the Eagles special teams MVP in 2005 and 2006. On defense, Mikell replaced the injured Sean Considine as the starting strong safety in 2007 and remained in that role through 2010. On November 28, 2004, Mikell notched his first career interception, outjumping tight endJeremy Shockey in the end zone for a pass thrown by quarterbackEli Manning late in the first half vs. the New York Giants. The play helped the Eagles preserve a 7-6 lead at halftime, and Philadelphia went on to win, 27-6, to clinch their fourth consecutive NFC East title. Mikell was a backup safety behind Pro Bowlers Michael Lewis and Brian Dawkins for the 2004 NFC Championship team and played in Super Bowl XXXIX. His most significant contribution on special teams came on October 23, 2005, when, with the Eagles trailing the San Diego Chargers, 17-13, late in the fourth quarter, he blocked a field goal attempt by placekickerNate Kaeding, which teammate Matt Ware returned 65 yards for a touchdown to secure a 20-17 win. It was the first time in Eagles history that a blocked field goal was returned for a touchdown. In a Christmas Day win at Dallas in 2006, Mikell propelled the Eagles with a key tackle for loss of running backMarion Barber on fourth down to finish off a goal-line stand. On February 27, 2007, Mikell inked a four-year contract with the Eagles, which prevented him from testing the free agent market. On January 9, 2009, Mikell was voted as a member of the 2008 NFL All-Pro Second-Team Defense. Mikell was named to the 2010 Pro Bowl after Adrian Wilson got hurt and Roman Harper could not play due to the Saints making it to Super Bowl XLIV.
St. Louis Rams
Mikell was signed by the St. Louis Rams on July 29, 2011. The team released him on March 11, 2013.
Carolina Panthers
Mikell was signed by the Carolina Panthers on September 2, 2013 to a one-year contract. Safety Haruki Nakamura was placed on injured reserve to open up spot on the 53-man roster. Mikell was expected to compete for the starting job at strong safety.
Career statistics
Personal life
Mikell returned to his native New Orleans, Louisiana, after Hurricane Katrinafor the first time on October 13, 2006, the day before the Philadelphia Eagles would play the New Orleans Saints. He was heartbroken by the vast devastation and conditions of disaster still remaining at his grandmother's home and in her neighborhood one year after the hurricane. Philadelphia NBC 10 profiled his visit on an October 14, 2006, telecast.