Eddie Lusk was born in Chicago, Illinois, United States, to parents who were ordained ministers in the Pentecostal Church. On Chicago's South Side they ran The Lusk Bible Way Center, and once Lusk was old enough he began playing the piano there. The blues music seeping from the nearby Pepper's Lounge proved a big distraction for the young Lusk. He became ordained himself in 1968, and gained a bachelor's degree in business administration at Northwestern University, but his love for the blues saw him installed at the Shiloh Academy. It was this connection that tempted Professor Longhair to bestow the title of 'Professor' on his young music disciple. An accomplished keyboard and piano player, Lusk backed Luther Allison for three years before his work saw him regularly used as a session and touring musician. Throughout the 1980s and early 1990s, Lusk recorded with Buddy Guy, Jimmy Johnson, Koko Taylor, Phil Guy, Jimmy Dawkins, Sunnyland Slim, Michael Coleman, and Nate Taylor. Lusk also toured nationally with some of those musicians and backed Fenton Robinson, Syl Johnson, and Otis Rush on the road. In 1985, Lusk joined Jimmy Dawkins, Eddie C. Campbell, Lowell Fulson and Anthony Palmer on Can't Sit Down!. With growing confidence and experience, Lusk formed his own band named the Professor's Blues Review, and with the singer Gloria Hardiman, recorded "Meet Me With Your Black Drawers On" for the 1987 Alligator Recordscompilation album, New Bluebloods. On his only solo album, Professor Strut, Hardiman was replaced by Karen Carroll. His work also later appeared on the various artists compilation, Black and Blue, Vol. 2. Lusk and Hardiman's version of "Meet Me With Your Black Drawers On" has become a hit in the Carolina beach music scene. He and his band appeared in the 1991 film, V. I. Warshawski, and later that year toured across Europe with Michael Coleman and Kenny Neal. In 1993, Lusk's prior recording entitled, Chicago Blues Festival 91, with Coleman and Neal was released. In mid-1992, Lusk was diagnosed with colorectal cancer, brought on by AIDS, and in a state of desperation committed suicide by jumping into the Chicago River.