Poorly differentiated thyroid cancer

Histopathology

• Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
• Round or oval nests or in trabeculae.
• Solid growth and presence of microfollicles, some of which contain dense colloid.
• Extrathyroidal extension and blood vessel invasion
• Foci of necrosis,
• Larger than 5 cm in greatest diameter at diagnosis

  Epidemiology

• PDTC affects predominantly females about 55 years of age