Pleuromutilin
Pleuromutilin and its derivatives are antibacterial drugs that inhibit protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.
This class of antibiotics includes the licensed drugs lefamulin, retapamulin, valnemulin and tiamulin and the investigational drug azamulin.History
Pleuromutilin was discovered as an antibiotic in 1950. It is derived from the fungus Clitopilus passeckerianus, and has also been found in Drosophila subatrata, Clitopilus scyphoides, and some other Clitopilus species.The total synthesis of pleuromutilin has been reported.
