Piceol


Piceol is a phenolic compound found in the needles and in mycorrhizal roots of Norway spruces. Picein is the glucoside of piceol.

Uses

Piceol is used in the synthesis of several pharmaceutical drugs including octopamine, sotalol, bamethan, and dyclonine.
Piceol can be used to make acetaminophen by oxime formation with hydroxylamine and subsequent Beckmann rearrangement in acid.
Anticonvulsants are also possible by Mannich reaction:

Metabolism

derivatives of piceol can be isolated from Ophryosporus macrodon.
4-Hydroxyacetophenone monooxygenase is an enzyme that transforms piceol into 4-hydroxyphenylacetic acid. This enzyme is found in Pseudomonas fluorescens.