Phosphoramidate
Phosphoramidates are a class of phosphorus compounds structurally related to phosphates via the substitution of an OR for a NR2. They are derivatives of phosphoramidic acids O=P2, O=P2.
A phosphorodiamidate is a phosphate that has two of its OH groups substituted by NR2 groups to give a species with the general formula O=P2.
The substitution of all three OH groups gives the phosphoric triamides, which are commonly referred to as phosphoramides.Examples
Two examples of natural phosphoramidates are phosphocreatine and the phosphoramidate formed when histidine residues in histidine kinases are phosphorylated.
An example of a phosphorodiamidate is Morpholino which is used in molecular biology.
