Phospholipase D1


Phospholipase D1 is an enzyme that in humans is encoded by the PLD1 gene.

Function

Phosphatidylcholine -specific phospholipases D catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis.

Interactions

Phospholipase D1 has been shown to interact with: