Cooper attended and played college football for the University of South Carolina. He was originally a defensive back before moving to wide receiver prior to the start of his freshman season. He played in 11 of 13 games his freshman season. He had three receptions for 54 receiving yards, 202 rushing yards, one rushing touchdown and also completed two of three pass attempts for 29 yards and a touchdown. Against Tennessee during his sophomore year in 2014, Cooper set the school single-game receiving yards record with 233. In the 2014 Independence Bowl against the Miami Hurricanes, he had nine receptions for 170 yards and a touchdown and was named the game's MVP. For the season, Cooper appeared in all 13 games and was named first team All-SEC after recording 69 receptions for 1,136 yards and nine touchdowns. He also ran for 200 yards with two rushing touchdowns and passed for 78 yards and two touchdowns. As a junior in 2015, Cooper had 873 receiving yards along with 111 rushing yards with 9 total touchdowns. He also had 55 return yards on 12 punt return opportunities. After his junior year, he announced his intentions to enter the 2016 NFL Draft.
Professional career
Los Angeles Rams
Cooper was drafted by the Los Angeles Rams in the fourth round of the 2016 NFL Draft. On June 9, 2016, Cooper signed a four-year contract with the team. He played in 10 games with three starts in his rookie season, recording 14 receptions for 106 yards while fulfilling kick return and occasional punt return duties. Following a 16–10 loss to Seattle in Week 5 of 2017, Cooper replaced a struggling Tavon Austin as the Rams' primary return man. In Week 6 of the 2017 season, Cooper scored the first NFL touchdown of his career with a 103-yard kick return touchdown to start the game in a 27–17 win over the Jacksonville Jaguars, earning him NFCSpecial TeamsPlayer of the Week honors. On December 19, 2017, Cooper was selected to the 2018 Pro Bowl as a return specialist. On September 12, 2018, Cooper was placed on injured reserve after suffering an ankle injury in Week 1. He was activated off injured reserve on November 19, 2018. On December 18, 2018, Cooper was released by the Rams.
Arizona Cardinals
On December 19, 2018, Cooper was claimed off waivers by the Arizona Cardinals. Appearing in two games, he returned six punts for 67 yards. On August 30, 2019, Cooper was released by the Cardinals.
Cincinnati Bengals
On September 1, 2019, Cooper was claimed off waivers by the Cincinnati Bengals. He saw limited action in the Bengals' season-opening 21–20 loss at the Seattle Seahawks, but recorded no receptions or yards. After being inactive for Week 2's game against the San Francisco 49ers, Cooper was waived on September 17, 2019.
Arizona Cardinals (second stint)
On October 1, 2019, Cooper was re-signed by the Arizona Cardinals.
Carolina Panthers
On March 20, 2020, Cooper signed a one-year contract with the Carolina Panthers.
