Blume swims for the Sigma Nordsjælland club in Denmark. At the 2012 Summer Olympics in London, Blume competed for the Danish team in five different events. In the 50 metre freestyle she failed to advance beyond the heats having finished 8th in her race and 26th fastest overall. In the 100 metre freestyle she again was eliminated in the first round after finishing 6th in her heat and 19th fastest overall. She won her heat of the 200 metre freestyle but did not advance to the next round after finishing 24th fastest overall. In the 4 × 100 metre freestyle relay Blume swam in a Danish quartet along with Mie Nielsen, Lotte Friis and Jeanette Ottesen; they qualified for the final, in which they finished sixth, setting a new Danish national record of 3:37.45. In the 4 × 100 metre medley relay Blume, Nielsen, Ottesen and Rikke Pedersen reached the final and finished seventh. Later in 2012 she won a gold medal at the World Short Course Championships in the 4 × 100 metre medley relay. She also won a bronze medal in the 4 × 50 metre freestyle relay. At the 2014 World Short Course Championships, Blume, Nielsen, Pedersen and Ottesen won a gold medal and set a new world record as they won the 4 × 50 metre medley relay. The quartet also won the gold medal in the 4 × 100 metre medley relay. In 2016 Blume won the 50 metre freestyle event at the Danish open gala. She was subsequently selected to compete at the 2016 Summer Olympics in Rio de Janeiro, Brazil, where she won 50 metre freestyle and also competed in 100 metre freestyle, the 4 × 100 metre freestyle relay and the 4 × 100 metre medley relay where she anchored the medley and thereby contributed to the Danish team winning a bronze medal, just 0.01 seconds behind the Australian team who won the silver medal. This was the first Olympic gold won by Denmark in swimming since Karen Harup at the 1948 Summer Olympics in London. Blume was Denmark's flag bearer at the closing ceremony.
2017 Career
Pernille Blume participated in Edinburgh International 2017 and competed in 50 m freestyle event, finishing with 24.51 and winning the gold medal and also winning gold in the 100 m freestyle with a time of 53.93. which was her first race after Rio Olympics. In April 2017 Pernille Blume participated in the Stockholm Swim Open; in the 50 m freestyle event she came second behind Sarah Sjöström with a time of 24.15.
