PA 107 begins at an intersection with US 6/US 11 on the border of the borough of Factoryville and Clinton Township in Wyoming County, heading north into Clinton Township on a two-lane undivided road. The route heads through forested areas, curving north-northeast and passing under Norfolk Southern's Sunbury Line. The road crosses into Nicholson Township and heads northeast through more wooded areas with some homes, turning east and passing to the south of Lake Sheridan. PA 107 enters Benton Township in Lackawanna County and continues south of the lake before running through more woodland with some fields and homes, coming to an intersection with PA 407 in Fleetville. The road heads through more rural areas, coming to an interchange with I-81 before crossing into Scott Township. The route runs through more woods with farmland and residences, becoming Heart Lake Road and forming the border between Greenfield Township to the north and Scott Township to the south. PA 107 passes through Tompkinsville prior to turning southeast to fully enter Scott Township and pass through agricultural areas as it reaches an intersection with PA 247. The road heads through more farmland and woodland with some homes, crossing into Carbondale Township. Here, the route crosses a forested mountain. PA 107 heads into the borough of Mayfield and comes to an interchange with US 6 Bus. Past this interchange, the road turns east and becomes Rushbrook Street and enters residential areas, briefly forming the border between Mayfield to the north and the borough of Jermyn to the south before fully entering Jermyn. The route passes over the Lackawanna River and a Delaware–Lackawanna Railroad line, heading into wooded areas and crossing back into Mayfield. PA 107 comes to its eastern terminus at an interchange with the US 6 freeway on the border of Mayfield and the borough of Archbald.
History
When Pennsylvania first legislated routes in 1911, what is now PA 107 was not given a number. PA 107 was designated in 1928 to run from US 11 in Factoryville east to US 6 in Jermyn along an unpaved road. By 1930, the section of the route between PA 407 in Fleetville and PA 247 was under construction. The entire length of PA 107 was paved in the 1930s. The eastern terminus of the route was cut back to the relocated US 6 at the Scranton-Carbondale Highway in the 1940s. PA 107 was extended back east to unnumbered Washington Avenue in Jermyn in the 1970s. In 1995, PA 107 was extended east from Washington Avenue to the newly-constructed US 6 freeway along a new two-lane road.
