P21-activated kinases

p21 activated kinases are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.
Members include:

PAK1, regulating cell motility and morphology
PAK2, possibly playing a role in apoptosis
PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
PAK4, a mediator of filopodia formation
PAK5, a mediator of filopodia formation
PAK6, involved in cytoskeleton rearrangement

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