Elnora Jean Wallace was born in Greenwood, Leflore County, Mississippi, United States, to a musical family, the seventh of 16 children of a Mississippisharecropper. Bruso won the West Tallahatchie High School Talent Show for singing, and began to perform in other schools in her local area. In 1976, she relocated to Chicago, Illinois when she was 19 years old, and began singing with a group called Scottie and the Oasis. In 1982, Scottie died but she continued performing with other ensembles and three years later joined Jimmy Dawkins' band. Bruso recorded her debut single, "Untrue Lover" on Dawkins' own Leric label. In 1985, she contributed vocals on one track of Dawkin's Feel the Blues release, billed as Nora Jean Wallace. Dawkins band, including Bruso, appeared at the Chicago Blues Festival in 1989. Bruso also participated on Kant Sheck Dees Bluze, another Dawkins release, this time on Earwig Records. In 1992, she left the music industry to raise her two sons, but almost a decade later was tempted back into a recording studio following the promptings of Billy Flynn, another member of Dawkins' backing band. Bruso supplied four vocal tracks for Blues and Love and, the same year, appeared as a backing singer with Dawkins again at the Chicago Blues Festival. She met and married Mark Bruso in 2002. Later that year she recorded Nora Jean Bruso Sings the Blues, which was released in 2003 by Red Hurricane Records. Bruso performed again at the 2003 Chicago Blues Festival, this time under her own name, and toured in Europe. In 2004, she was nominated for two W.C. Handy Awards, as 'Best New Artist' and 'Best Traditional Female Artist'. The same year, after having signed a recording contract with Severn Records, she released Going Back to Mississippi. This was more of a commercial success reaching number five on Living Blues radio chart and number one on XM satellite radio. In June 2004, she returned and performed on the main stage at the Chicago Blues Festival with her own band. Her ensemble at that time included Carl Weathersby, Bruce Beglin and Brian Lupo. These musicians, amongst others, played on Going Back to Mississippi. Her live appearances continued and included the King Biscuit Blues Festival, Rawa Blues Festival, Notodden Blues Festival, Briggs Farm Blues Festival, Cape May Jazz Festival and Pocono Blues Festival. She appeared again at the Chicago Blues Festival in 2011. In 2011, the Chicago Sun-Times noted that her collaboration with Little Bobby for the latter's album, Good Blues, "... helped push Nora Jean to her seventh Blues Music Award nomination for 'Best Traditional Female Blues Performer'." In June 2014, she appeared with Lurrie Bell's Chicago Blues Band in Pyla-sur-Mer, France. In July 2015, she performed at the Kingston Mines club in Chicago. Bruso is currently based in La Porte, Indiana.