The village fell within the county of Renfrewshire until 1926, when it was incorporated into the City of Glasgow. The change in local government was mainly related to education and community services such as roads, water, sewerage and housing. Consisting of just a few streets prior to its incorporation into Glasgow, Nitshill grew on a small scale with cottage flats prior to World War II, after which it was substantially expanded to accommodate people relocated during the Glasgow slum clearances in the 1950s and 1960s. on Nitshill Road The wider area, sited on the main Glasgow-Kilmarnock road and rail networks and including the post-WWII housing schemes of South Nitshill and Craigbank, became increasingly marked by multiple socio-economic issues. However, there has been a move towards improving the district with the regeneration/demolition of much of the housing and schools, and the building of The Glasgow MuseumsResource Centre, a purpose-built museum storage facility and visitor centre which houses the Nitshill Open Museum. There is one small tower block in the area, adjacent to the shopping precinct, the only such structure in that part of Glasgow. Part of the city's Greater Pollok ward, Nitshill is classed as a low socio-economic area. Studies have confirmed a strong association between deprivation and crime. It is no surprise, therefore, to find that the highest rates of crime in residential areas in Glasgow are to be found in the most deprived areas of the city. This link was highlighted in a report relating to a knife murder committed by a bar manager in a Nitshill pub in 2010. Nitshill railway station is on the Glasgow South Western Line and has a memorial to the former station clerk John Meikle, killed in action in France in 1918, aged 19, and awarded a posthumous Victoria Cross. The railway line is the southern boundary of Nitshill proper while the northern limit is the Levern Water. The poet and folk singer Jock Purdon was born and grew up in Nitshill.
On 15 March 1851, an explosion at the Victoria coal pit killed 61 of the 63 men and boys in the mine at the time. Two survivors were rescued 45 hours after the explosion. A memorial to the disaster stands off the main road at Nitshill station, beside the local war memorial.